Fabrication and biocompatibility of BNNT supramolecular complexes and PCL/BNNTs nanofibers

Hyphenated electrospinning electrospraying is a versatile method for synthesizing polymeric functional materials with fascinating and tuneable characteristics. In this paper, previously unreported clusters of boron nitride nanotubes (BNNTs) their hybrid nanofibers ɛ-polycaprolactone (PCL) were fabricated successfully. For instance, biocompatible nano fibrous mat may have potent to encapsulate common anticancer drugs such as doxorubicin (DOX), cisplatin Fluorouracil (5FU) minimize the most lethal side effect, cardiotoxicity, improve chemotherapy manage cardiotoxicity in cancer patients. BNNTs supramolecular solution was prepared controllable dispersion agglomeration features. Furthermore, synthesized PCL including (PCL/BNNTs) exhibit favourable qualities terms mechanical thermal strength, hydrophobicity biocompatibility. Different microscopic analytical examinations as: Field emission scanning electron microscopy (FESEM), Furrier transform spectroscopy (FT-IR), Dynamic calorimetry (DSC) MTT assay performed. then subjected electrospraying. Simultaneously conducted provide nanofiber net-like film consisting BNNT nano-capsulated beads (∼100 nm ∼1 µm). PCL/BNNTs average diameters 350 ± 50 depended on various conditions. The results cytotoxicity cardiac cell line (H9c2 cells) reveal that are more rather than isolated BNNTs.